I’m being positive! I think she could be referring to Cas and how Sam & Dean (oh and Bobby) deal with him. I think (I hope!) they’ve left it open for Cas to return and depending on how mad we go at the prospect of never seeing Cas again, I think (again hope!) they’ll either go down one storyline route or the other!
I have thought though that Cas could be the the big bad that they’ve all talked about this season. Writers and actors have been quoted as saying that Season 7’s big bad is something Sam & Dean never come across before and can no longer use their hunter resources against - this could be Godstiel (!!) which would mean Misha would be around a lot longer, just not as frequently, which I think I could handle. Just a thought!
This is the good thing about American shows as opposed to British ones - Brits make everything final all in advance. Supernatural can change things at the last minute, because they’re still making it, like, a week before the deadline. Something silly like that. But there are upsides! Like this! Yay!